I wrote something I called “The Most Important Thing” almost exactly 1 year ago. It was mostly a long list of questions. I have come upon more questions. I am not sure if any of them is the most important question or not (probably not in this list).
Maybe the most important question is:

How do you determine what the most important thing to think about is?

So here is my list of questions. Have you thought about any of them?

Why are people gay? Is it a natural (coming from some brain chemistry) behavior or is it induced by something that happened to them during their life (trauma)?
What is a natural behavior?
What other actions are induced by some action?
Are most neurosis brought on by some action that happens to people?
What is the most important thing for the future?
Do we want to reduce deaths?
Do we want to push death off later?
Is longer life the goal?
Is avoiding an unplanned death good?
What is a planned death? No one plans to die.
What is a quality life?

Why don’t women go bald?
What is the carrying capacity of the Earth? (How many people can the earth support).

What makes someone smart?
Connections in their brain?
Why can’t we all be savants, photographic memory, pick all dates from history, do large math equations in our heads?
Why are not all successful people “smart”?
Why are all “smart” people not “successful?
Why are some people who are successful “not as smart”?
How is smartness measured? Street smart vs. Book smart
How is success measured?

How do 2 particles get entangled?
Do they get un-entangled sometime?
Can more than 2 particles be entangled?
Wouldn’t all particles eventually get entangled together?

Why do people worry about “using” water? It can’t be destroyed. It can only be contaminated, and contamination can be cleaned.
There are very few things on the earth that “consume” water. It is always returned, sometimes just not in the same place.
How many people will the earth sustainably support?
We will be better able to ration food as we get more technical since fewer people will be making the food. This is a good argument to be the people making the food! At the same time, this should allow us to take care of everyone’s hunger needs. There should be abundance. In fact there already is!
Why do some people die of hunger each day? (21,000 according to this site) That’s ridiculous

Why did the 1918 flu epidemic end so quickly? Why didn’t it just spiral out of control and kill everyone?
How do they get genes in a GMO?
Gene Gun
Bacteria
Does a trans-gene have to go on a specific chromosome?
Does a trans-gene have to go in a specific part of a chromosome?
If so how do they get it in the right place?
Why do we have 23 pairs of chromosomes instead of 1?
How many examples of fusion genes are there in different animals?
Why is our GULO (vitamin C gene) apparently broken?
Is it broken?
Do we want to fix it?
What other animals have a mutated GULO gene? (fruit bats)
Why don’t we make all 20 essential amino acids we need?
Would we want to turn that ability back on if we could?

How are there always fresh fruits at grocery stores? Who is harvesting tomatoes all year?
How old is the apple you are buying from the store?
Yet according to this study, antioxidant activity in apples gradually drops off after three months of storage in the cold. An apple stored for nearly a year? It will have almost no antioxidants remaining in it whatsoever.
What exactly happens to the antioxidants? They break down? Into what?

What is someone paid if a gas pipeline is forced onto their land?

Why are there homeless people?
Why don’t they get social security money?
How would we provide them a safe place to live?
Do they want a place to live? (you’d sure think so)

Below is a line of questions I worked down after a friend asked the first one. I have included links to some of the answers I found.
Q. Why don’t Jewish people do sacrifices today if they don’t think the Messiah has come yet?
A. We stopped offering sacrifices because we do not have a proper place to offer them. – Link
Q. So that brings up the question – Why don’t the Jews rebuild the temple?
A. “Truthfully, we don’t even know how to construct it.” – Link
Q. How are you supposed to build something that they don’t know how to build?
Comment: “It is forbidden to enter the Temple area in a state of ritual impurity. The only way to become ritually pure is with the ashes of a red heifer, which presents its own set of challenges.”
Q. Where is the red heifer?
A. “The cattle rancher is utilizing the technique of implanting the frozen embryos of the Red Angus cattle, which originally come from North America in Israeli domestic cattle.” – Link
Q. Should not God provide the Red Heifer?(from a commenter on this article, not my question)

What are some of the most burning questions you have? Why haven’t you sought the answers yet!